Lipid Nanoparticles for Ocular Gene Delivery
نویسندگان
چکیده
منابع مشابه
Lipid Nanoparticles for Ocular Gene Delivery
Lipids contain hydrocarbons and are the building blocks of cells. Lipids can naturally form themselves into nano-films and nano-structures, micelles, reverse micelles, and liposomes. Micelles or reverse micelles are monolayer structures, whereas liposomes are bilayer structures. Liposomes have been recognized as carriers for drug delivery. Solid lipid nanoparticles and lipoplex (liposome-polyca...
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1 Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal; 2 Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Vila Real, Portugal, 3 Department of Biology and Environment, University of Trás-os-Montes e Alto Douro (UTAD), Vila Real, Portugal; 4 Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Barcel...
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With the advent of multifunctional nano delivery systems, simultaneous imaging and therapy aspires to detect and treat tumors at a very early stage with promising out‐ comes. In this context, numerous anti-cancer drug/gene delivery systems have been ex‐ plored with the primary aim to increase the treatment efficacy without compromising safety. Secondary goals include enhancing bioavailability, ...
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In the present study we have developed lipid nanoparticle (LN) dispersions based on a multiple emulsion technique for encapsulation of hydrophilic drugs or/and proteins by a full factorial design. In order to increase ocular retention time and mucoadhesion by electrostatic attraction, a cationic lipid, namely cetyltrimethylammonium bromide (CTAB), was added in the lipid matrix of the optimal LN...
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Lipid based drug delivery systems have been widely studied and reported over the past decade and offer a useful alternative to other colloidal drug delivery systems. Skin is a popular route of drug delivery for locally and systemically acting drugs and nanoparticles are reported as a potential formulation strategy for dermal delivery. Although the skin acts as a natural physical barrier against...
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ژورنال
عنوان ژورنال: Journal of Functional Biomaterials
سال: 2015
ISSN: 2079-4983
DOI: 10.3390/jfb6020379